Publications

Pseudomonas aeruginosa defends against phages through type IV pilus glycosylation. Harvey H, Bondy-Denomy J, Marquis H, Sztanko KM, Davidson AR, Burrows LL. Nat Microbiol. 2017 Nov 13. doi: 10.1038/s41564-017-0061-y. [Epub ahead of print] PMID: 29133883

Disabling Cas9 by an anti-CRISPR DNA mimic. Shin J, Jiang F, Liu JJ, Bray NL, Rauch BJ, Baik SH, Nogales E, Bondy-Denomy J, Corn JE, Doudna JA. Sci Adv. 2017 Jul 12;3(7):e1701620. doi: 10.1126/sciadv.1701620. eCollection 2017 Jul. PMID: 28706995

Cas1 and the Csy complex are opposing regulators of Cas2/3 nuclease activity. Rollins MF, Chowdhury S, Carter J, Golden SM, Wilkinson RA, Bondy-Denomy J, Lander GC, Wiedenheft B. Proc Natl Acad Sci U S A. 2017 Apr 24. pii: 201616395. doi: 10.1073/pnas.1616395114. [Epub ahead of print]

Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex. Chowdhury S, Carter J, Rollins MF, Golden SM, Jackson RN, Hoffmann C, Nosaka L, Bondy-Denomy J, Maxwell KL, Davidson AR, Fischer ER, Lander GC, Wiedenheft B. Cell. 2017 Mar 23;169(1):47-57.e11. doi: 10.1016/j.cell.2017.03.012.

Inhibition of CRISPR-Cas9 with Bacteriophage Proteins. Rauch BJ, Silvis MR, Hultquist JF, Waters CS, McGregor MJ, Krogan NJ, Bondy-Denomy J. Cell. 2017 Jan 12;168(1-2):150-158.e10. doi: 10.1016/j.cell.2016.12.009 (open access link; altmetric)

Quorum sensing controls the Pseudomonas aeruginosa CRISPR-Cas adaptive immune system. Høyland-Kroghsbo NM, Paczkowski J, Mukherjee S, Broniewski J, Westra E, Bondy-Denomy J, Bassler BL. Proc Natl Acad Sci U S A. 2017 Jan 3;114(1):131-135. doi: 10.1073/pnas.1617415113.

The solution structure of an anti-CRISPR protein. Maxwell KL, Garcia B, Bondy-Denomy J, Bona D, Hidalgo-Reyes Y, Davidson AR.Nat Commun. 2016 Oct 11;7:13134. doi: 10.1038/ncomms13134.

Prophages mediate defense against phage infection through diverse mechanisms. Bondy-Denomy J, Qian J, Westra ER, Buckling A, Guttman DS, Davidson AR, Maxwell KL. ISME J. 2016 Jun 3. doi: 10.1038/ismej.2016.79.

The diversity-generating benefits of a prokaryotic adaptive immune system. van Houte S, Ekroth AK, Broniewski JM, Chabas H, Ben Ashby, Bondy-Denomy J, Gandon S, Boots M, Paterson S, Buckling A, Westra ER. Nature. 2016 Apr 13. doi: 10.1038/nature17436.

Active and Adaptive Legionella CRISPR-Cas reveals a recurrent challenge to the pathogen. Rao C, Guyard C, Pelaz C, Wasserscheid J, Bondy-Denomy J, Dewar K, Ensminger AW. Cell Microbiol. 2016 Mar 3. doi: 10.1111/cmi.12586.

Foreign DNA acquisition by the I-F CRISPR-Cas system requires all components of the interference machinery. Vorontsova D, Datsenko KA, Medvedeva S, Bondy-Denomy J, Savitskaya EE, Pougach K, Logacheva M, Wiedenheft B, Davidson AR, Severinov K, Semenova E. Nucleic Acids Res. 2015 Dec 15;43(22):10848-60. doi: 10.1093/nar/gkv1261.

Multiple mechanisms for CRISPR–Cas inhibition by anti-CRISPR proteinsBondy-Denomy J, Garcia B, Strum S, Du M, Rollins MF, Hidalgo-Reyes Y, Wiedenheft B, Maxwell K.L. & Alan R. Davidson A.R. Nature. 2015. doi:10.1038/nature15254.

Parasite Exposure Drives Selective Evolution of Constitutive versus Inducible Defense. Westra ER, van Houte S, Oyesiku-Blakemore S, Makin B, Broniewski JM, Best A, Bondy-Denomy J, Davidson A, Boots M, Buckling A. Curr Biol. 2015 Apr 20;25(8):1043-9. doi: 10.1016/j.cub.2015.01.065.

A new group of phage anti-CRISPR genes inhibits the type I-E CRISPR-Cas system of Pseudomonas aeruginosa. Pawluk A, Bondy-Denomy J, Cheung VH, Maxwell KL, Davidson AR. MBio. 2014 Apr 15;5(2):e00896. doi: 10.1128/mBio.00896-14.

Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system. Bondy-Denomy J, Pawluk A, Maxwell KL, Davidson AR. Nature. 2013 Jan 17;493(7432):429-32. doi: 10.1038/nature11723.

Efficacy of bacteriophage treatment on Pseudomonas aeruginosa biofilms. Phee A, Bondy-Denomy J, Kishen A, Basrani B, Azarpazhooh A, Maxwell K. J Endod. 2013 Mar;39(3):364-9. doi: 10.1016/j.joen.2012.10.023.

The CRISPR/Cas adaptive immune system of Pseudomonas aeruginosa mediates resistance to naturally occurring and engineered phages. *Cady KC, *Bondy-Denomy J, Heussler GE, Davidson AR, O'Toole GA. J Bacteriol. 2012 Nov;194(21):5728-38. doi: 10.1128/JB.01184-12.

Commentary & Reviews

The Discovery, Mechanisms, and Evolutionary Impact of Anti-CRISPRs. Borges AL, Davidson AR, Bondy-Denomy J. Annu Rev Virol. 2017 Jul 27. doi:10.1146/annurev-virology-101416-041616. [Epub ahead of print] (open access link)

CRISPR control of virulence in Pseudomonas aeruginosa. Wiedenheft B, Bondy-Denomy J. Cell Res. 2017 Jan 13. doi: 10.1038/cr.2017.6.

When a virus is not a parasite: the beneficial effects of prophages on bacterial fitness. Bondy-Denomy J, Davidson AR. J Microbiol. 2014 Mar;52(3):235-42. doi: 10.1007/s12275-014-4083-3. Epub 2014 Mar 1.

To acquire or resist: the complex biological effects of CRISPR-Cas systems. Bondy-Denomy J, Davidson AR. Trends Microbiol. 2014 Apr;22(4):218-25. doi: 10.1016/j.tim.2014.01.007. Epub 2014 Feb 26.